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\u0645\u064a\u0643\u0631\u0648\u0628\u064a\u0648\u062a\u0627 \u0627\u0644\u0623\u0645\u0639\u0627\u0621. \u062a\u0634\u064a\u0631 \u0627\u0644\u062f\u0644\u0627\u0626\u0644 \u0627\u0644\u0646\u0627\u0634\u0626\u0629 \u0625\u0644\u0649 \u0623\u0646\u0651 \u0645\u064a\u0643\u0631\u0648\u0628\u0627\u062a \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0645\u062a\u0648\u0631\u0651\u0637\u0629 \u0641\u064a \u062a\u0646\u0638\u064a\u0645 \u0635\u062d\u0651\u0629 \u0627\u0644\u0639\u0627\u0626\u0644\u060c \u0641\u064a \u062d\u064a\u0646 \u0642\u062f \u064a\u0624\u062f\u0651\u064a \u0639\u062f\u0645 \u0627\u0644\u062a\u0648\u0627\u0632\u0646 \u0641\u064a \u0645\u064a\u0643\u0631\u0648\u0628\u064a\u0648\u062a\u0627 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0625\u0644\u0649 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0634\u0627\u0643\u0644 \u0627\u0644\u0645\u0639\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u064f\u0639\u0631\u0641 \u0639\u0627\u062f\u0629\u064b \u0628\u0627\u0633\u0645 \u062f\u064a\u0633\u0628\u064a\u0648\u0633\u064a\u0632 (Dysbiosis)\u060c \u0648\u0641\u064a \u0645\u0627 \u064a\u0644\u064a \u0639\u0631\u0636 \u0645\u0641\u0635\u0651\u0644 \u0644\u0647\u0630\u0647 \u0627\u0644\u0648\u0638\u0627\u0626\u0641:<\/p>\n<ul>\n<li><strong>\u0627\u0644\u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0628\u0646\u0627\u0626\u064a\u0629 \u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 <\/strong><\/li>\n<\/ul>\n<p>\u062a\u0634\u0643\u0651\u0644 \u0623\u0645\u0639\u0627\u0621 \u0627\u0644\u062f\u0648\u0627\u062c\u0646 \u062e\u0637\u0651 \u0627\u0644\u062f\u0641\u0627\u0639 \u0627\u0644\u0623\u0648\u0651\u0644 \u0641\u064a \u062c\u0633\u0645 \u0627\u0644\u0637\u0627\u0626\u0631 \u0648\u0630\u0644\u0643 \u0644\u062d\u0645\u0627\u064a\u062a\u0647 \u0648\u0645\u0633\u0627\u0646\u062f\u062a\u0647 \u0648\u062a\u0642\u0648\u064a\u0629 \u0645\u0646\u0627\u0639\u062a\u0647 \u0645\u062b\u0644\u0647\u0627 \u0645\u062b\u0644 \u0628\u0642\u064a\u0629 \u0623\u0639\u0636\u0627\u0621 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u060c \u0648\u0646\u0639\u062a\u0628\u0631 \u0627\u0644\u0638\u0647\u0627\u0631\u0629 \u0627\u0644\u0645\u0628\u0637\u0651\u0646\u0629 \u0644\u0623\u0645\u0639\u0627\u0621 \u0627\u0644\u062f\u0648\u0627\u062c\u0646 \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u0637\u0628\u0642\u0629 \u0623\u062d\u0627\u062f\u064a\u0629 \u062a\u062a\u0643\u0648\u0651\u0646 \u0645\u0646 \u0623\u0646\u0648\u0627\u0639 \u0645\u062e\u062a\u0644\u0641\u0629 \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 (Intercellular Junctions Complex)\u060c \u062a\u062d\u0627\u0641\u0638 \u0627\u0644\u062a\u062c\u0645\u0651\u0639\u0627\u062a \u0627\u0644\u0648\u0627\u0635\u0644\u0629 \u0628\u064a\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u0627\u0644\u0648\u0635\u0644\u0627\u062a \u0627\u0644\u0636\u064a\u0642\u0629 (Gut Barrier Integrity) \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0628\u064a\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0638\u0647\u0627\u0631\u064a\u0629 \u0627\u0644\u0645\u0639\u0648\u064a\u0629 \u0639\u0644\u0649 \u0633\u0644\u0627\u0645\u0629 \u062d\u0627\u062c\u0632 \u0627\u0644\u0642\u0646\u0627\u0629 \u0627\u0644\u0647\u0636\u0645\u064a\u0629. \u062d\u064a\u062b \u062a\u0631\u0628\u0637 \u0647\u0630\u0647 \u0627\u0644\u0648\u0635\u0644\u0627\u062a \u0627\u0644\u0636\u064a\u0642\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0638\u0647\u0627\u0631\u064a\u0629 \u0627\u0644\u0645\u0639\u0648\u064a\u0629 \u0628\u0628\u0639\u0636\u0647\u0627 \u0627\u0644\u0628\u0639\u0636 \u0631\u0628\u0637\u0627\u064b \u0645\u062d\u0643\u0645\u0627\u064b \u0648\u0630\u0644\u0643 \u0644\u0645\u0646\u0639 \u062f\u062e\u0648\u0644 \u0645\u0633\u0628\u0651\u0628\u0627\u062a \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u0639\u0648\u064a\u0629 \u0643\u0627\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0627 \u0623\u0648 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a\u060c \u0625\u0644\u0649 \u0627\u0644\u0635\u0641\u064a\u062d\u0629 \u0627\u0644\u0645\u062e\u0635\u0648\u0635\u0629 (Lamina Propria)\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u0627\u0644\u062d\u0641\u0627\u0638 \u0639\u0644\u0649 \u062a\u0648\u0627\u0632\u0646 \u0627\u0644\u0623\u0645\u0639\u0627\u0621. \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0644\u062c\u0631\u0627\u062b\u064a\u0645 \u0627\u0644\u0645\u0639\u0648\u064a\u0629 (Intestinal Microflora) \u0627\u0644\u062a\u064a \u062a\u0645\u0646\u0639 \u062a\u0643\u0627\u062b\u0631 \u0648\u0627\u0646\u062a\u0634\u0627\u0631 \u0648\u0627\u0633\u062a\u0639\u0645\u0627\u0631 \u0645\u0633\u0628\u0651\u0628\u0627\u062a \u0627\u0644\u0623\u0645\u0631\u0627\u0636 (Pathogenic Bacteria)\u060c \u0647\u0630\u0627 \u0645\u0646 \u0646\u0627\u062d\u064a\u0629\u060c \u0648\u0645\u0646 \u0646\u0627\u062d\u064a\u0629 \u0623\u062e\u0631\u0649 \u062a\u0639\u0645\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0638\u0647\u0627\u0631\u064a\u0629 \u0627\u0644\u0645\u0639\u0648\u064a\u0629 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0625\u0641\u0631\u0627\u0632\u0627\u062a\u0647\u0627 \u062f\u0627\u062e\u0644 \u0627\u0644\u0642\u0646\u0627\u0629 \u0639\u0644\u0649 \u0645\u0646\u0639 \u062f\u062e\u0648\u0644 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u0645\u0631\u0636\u0629 \u0625\u0644\u0649 \u0627\u0644\u0642\u0646\u0627\u0629 \u0627\u0644\u0647\u0636\u0645\u064a\u0629. \u062d\u064a\u062b \u064a\u063a\u0637\u064a \u0627\u0644\u0633\u0637\u062d \u0627\u0644\u062e\u0627\u0631\u062c\u064a \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0638\u0647\u0627\u0631\u064a\u0629 \u0627\u0644\u0645\u0639\u0648\u064a\u0629 \u0628\u0637\u0628\u0642\u0629 \u0645\u062e\u0627\u0637\u064a\u0629 (Mucus Layer)\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u0648\u0641\u0651\u0631 \u062d\u0627\u062c\u0632\u0627\u064b \u0645\u0646\u064a\u0639\u0627\u064b \u0645\u0646\u062a\u0634\u0631\u0627\u064b (Diffusive Layer) \u0628\u064a\u0646 \u0627\u0644\u062c\u0631\u0627\u062b\u064a\u0645 \u0627\u0644\u0645\u0639\u0648\u064a\u0629 \u0648\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0638\u0647\u0627\u0631\u064a\u0629\u060c \u062d\u064a\u062b \u064a\u0642\u0648\u0645 \u0628\u0625\u064f\u0641\u0631\u0627\u0632 \u0627\u0644\u0645\u062e\u0627\u0637 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0643\u0623\u0633\u064a\u0629 \u0627\u0644\u0645\u0639\u0648\u064a\u0629 (Goblet Cell) \u0627\u0644\u0630\u064a \u064a\u062a\u0643\u0648\u0651\u0646 \u0645\u0646 95% \u0645\u0627\u0621 \u06485% \u0641\u0642\u0637 \u0645\u0646 \u0645\u062d\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0645\u062e\u0627\u0637 \u062a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0623\u0645\u0644\u0627\u062d \u0648\u062f\u0647\u0648\u0646 \u0648\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u062c\u0644\u0627\u064a\u0643\u0648\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u064a\u0648\u0633\u064a\u0646 \u0627\u0644\u0645\u0643\u0648\u0651\u0646\u0629 \u0644\u0644\u062c\u0644 (Gel) \u0648\u0627\u0644\u0644\u064a\u0632\u0648\u0632\u064a\u0645 (Muc2) \u00a0\u0648Muc5a \u0648Muc5b \u00a0\u0648Muc6\u0648\u0647\u064a \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u0647\u0644\u0627\u0645\u060c \u0648\u064a\u062a\u0634\u0643\u0651\u0644 \u0627\u0644\u0645\u064a\u0648\u0633\u064a\u0646 \u0641\u064a \u0623\u0645\u0639\u0627\u0621 \u0627\u0644\u062f\u062c\u0627\u062c.<\/p>\n<p>\u062a\u0639\u062f\u0651 \u0638\u0647\u0627\u0631\u0629 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0627\u0644\u0648\u0627\u062c\u0647\u0629 \u0648\u0627\u0644\u062c\u062f\u0627\u0631 \u0627\u0644\u0641\u0627\u0635\u0644 \u0628\u064a\u0646 \u0645\u064a\u0643\u0631\u0648\u0628\u0627\u062a \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0648\u0627\u0644\u062c\u0633\u0645\u060c \u0648\u062a\u0645\u062b\u0651\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0639\u0648\u064a\u0629 \u0623\u0643\u062b\u0631 \u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0641\u064a \u0627\u0644\u0638\u0647\u0627\u0631\u0629 \u0627\u0644\u0645\u0628\u0651\u0637\u0646\u0629 \u0644\u0642\u0646\u0627\u0629 \u0623\u0645\u0639\u0627\u0621 \u0627\u0644\u062f\u0648\u0627\u062c\u0646\u060c \u0648\u0647\u064a \u0639\u0628\u0627\u0631\u0647 \u0639\u0646 \u062e\u0644\u0627\u064a\u0627 \u0645\u0639\u0648\u064a\u0629 \u062a\u0645\u062b\u0651\u0644 \u0623\u0643\u062b\u0631 \u0645\u0646 80% \u0645\u0646 \u0628\u0637\u0627\u0646\u0629 \u0627\u0644\u0623\u0645\u0639\u0627\u0621.<\/p>\n<p>\u062a\u062a\u0645\u062b\u0651\u0644 \u0627\u0644\u0648\u0638\u064a\u0641\u0629 \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u0629 \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0639\u0648\u064a\u0629 \u0641\u064a \u0647\u0636\u0645 \u0627\u0644\u0637\u0639\u0627\u0645 \u0648\u0627\u0645\u062a\u0635\u0627\u0635\u0647\u060c \u062a\u062d\u062a\u0648\u064a \u0627\u0644\u0637\u0628\u0642\u0629 \u0627\u0644\u0623\u062d\u0627\u062f\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0643\u0623\u0633\u064a\u0629\u060c \u0627\u0644\u062a\u064a \u062a\u0641\u0631\u0632 \u0627\u0644\u0645\u062e\u0627\u0637 \u0648\u062a\u062a\u0648\u0627\u062c\u062f \u0628\u0643\u062b\u0631\u0629 \u0641\u064a \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 26% \u0641\u064a \u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u0644\u0641\u0627\u0626\u0641\u064a (Ileum) \u064823% \u0641\u064a \u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u0635\u0627\u0626\u0645 (jejunum)\u060c \u0643\u0645\u0627 \u064a\u0648\u062c\u062f \u0646\u0648\u0639 \u062b\u0627\u0644\u062b \u0645\u0647\u0645 \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u0647\u064a \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0635\u0645\u0627\u0621 \u0627\u0644\u0645\u0639\u0648\u064a\u0629 (Enteroendocrine Cells)\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u062a\u0645\u062b\u0651\u0644 \u0648\u0638\u064a\u0641\u062a\u0647\u0627 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629 \u0641\u064a \u0625\u0641\u0631\u0627\u0632 \u0627\u0644\u0625\u0646\u0632\u064a\u0645\u0627\u062a \u0644\u062a\u0639\u0632\u064a\u0632 \u0647\u0636\u0645 \u0645\u0643\u0648\u0651\u0646\u0627\u062a \u0627\u0644\u063a\u0630\u0627\u0621\u060c \u0643\u0645\u0627 \u062a\u0642\u0648\u0645 \u0647\u0630\u0647 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0628\u0625\u0646\u062a\u0627\u062c \u0647\u0631\u0645\u0648\u0646\u0627\u062a \u062a\u0641\u0631\u0632\u0647\u0627 \u0641\u064a \u0645\u062c\u0631\u0649 \u0627\u0644\u062f\u0645 \u0628\u062f\u0644\u0627\u064b \u0645\u0646 \u062a\u062c\u0648\u064a\u0641 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0648\u062a\u0639\u062f\u0651 \u0647\u0630\u0647 \u0646\u0642\u0637\u0629 \u0645\u0647\u0645\u0629 \u0641\u064a \u0627\u0644\u0625\u0643\u062a\u0634\u0627\u0641\u0627\u062a \u0627\u0644\u062d\u062f\u064a\u062b\u0629 \u0644\u0644\u0639\u0644\u0645\u0627\u0621. \u062a\u062a\u0648\u0627\u062c\u062f \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0635\u0645\u0627\u0621 \u0627\u0644\u0645\u0639\u0648\u064a\u0629 \u0628\u0634\u0643\u0644 \u0636\u0626\u064a\u0644 \u0641\u064a \u0638\u0647\u0627\u0631\u0629 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0648\u062a\u0645\u062b\u0644 \u062d\u0648\u0627\u0644\u064a 1% \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627.<\/p>\n<p>\u0647\u0646\u0627\u0644\u0643 \u0623\u064a\u0636\u0627\u064b \u062e\u0644\u0627\u064a\u0627 \u062a\u0633\u0645\u0651\u0649 \u062e\u0644\u0627\u064a\u0627 \u0628\u0627\u0646\u064a\u062b (Paneth Cells)\u060c \u0648\u0647\u064a \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u062e\u0644\u0627\u064a\u0627 \u0638\u0647\u0627\u0631\u064a\u0629 \u0645\u0639\u0648\u064a\u0629 \u0645\u062a\u062e\u0635\u0651\u0635\u0629\u060c \u062a\u0642\u0639 \u0641\u064a \u0642\u0627\u0639\u062f\u0629 \u0627\u0644\u062a\u062c\u0627\u0648\u064a\u0641 \u0627\u0644\u0645\u0639\u0648\u064a \u0648\u0627\u0644\u062a\u064a \u062a\u0642\u0648\u0645 \u0628\u0625\u0641\u0631\u0627\u0632 \u0645\u0631\u0643\u0651\u0628\u0627\u062a \u0645\u0647\u0645\u0629 \u062c\u062f\u0627\u064b \u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u062c\u0631\u0627\u062b\u064a\u0645 \u0623\u0648 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0645\u062b\u0644 \u0627\u0644\u0641\u0648\u0633\u0641\u0648\u0644\u064a\u0628\u0627\u0632 \u0648\u0627\u0644\u0644\u064a\u0632\u0648\u0632\u064a\u0645 \u0648\u0627\u0644\u0623\u0644\u0641\u0627 \u062f\u064a\u0641\u064a\u0646\u0633\u064a\u0646. \u062d\u064a\u062b \u0643\u0634\u0641\u062a \u0646\u062a\u0627\u0626\u062c \u0622\u062e\u0631 \u0623\u0628\u062d\u0627\u062b \u0627\u0644\u0639\u0644\u0645\u0627\u0621 \u0639\u0646 \u0648\u062c\u0648\u062f \u062b\u0644\u0627\u062b\u0629 \u0623\u0646\u0648\u0627\u0639 \u0645\u0646 \u062e\u0644\u0627\u064a\u0627 \u0628\u0627\u0646\u064a\u062b \u0641\u064a \u0627\u0644\u062f\u0648\u0627\u062c\u0646 \u062d\u062a\u0649 \u0627\u0644\u0622\u0646\u060c \u0648\u062a\u0634\u0645\u0644 \u0647\u0630\u0647 \u0627\u0644\u0623\u0646\u0648\u0627\u0639 \u0645\u0627 \u064a\u0644\u064a:<\/p>\n<ol>\n<li>\u062e\u0644\u0627\u064a\u0627 \u0646\u0648\u0639 \u0633\u064a (Type C) \u0648\u062a\u0633\u0645\u0651\u0649 \u0628\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a\u0629 \u0648\u0627\u0644\u062a\u064a \u062a\u0648\u062c\u062f \u063a\u0627\u0644\u0628\u0627\u064b \u0641\u064a \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0648\u0642\u0646\u0627\u0629 \u0627\u0644\u0628\u064a\u0636.<\/li>\n<li>\u062e\u0644\u0627\u064a\u0627 \u0646\u0648\u0639 \u062c\u064a (Type G) \u0623\u0648 \u0646\u0648\u0639 Goose \u0648\u0627\u0644\u0645\u0646\u062a\u0634\u0631\u0629 \u0641\u064a \u0627\u0644\u0631\u0626\u062a\u064a\u0646 \u0648\u0646\u062e\u0627\u0639 \u0627\u0644\u0639\u0638\u0627\u0645.<\/li>\n<li>\u062e\u0644\u0627\u064a\u0627 \u0646\u0648\u0639 \u062c\u064a 2 (Type G2) \u0648\u0627\u0644\u062a\u064a \u064a\u062a\u0645\u0651 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646\u0647\u0627 \u0641\u064a \u0627\u0644\u0643\u0628\u062f \u0648\u0627\u0644\u0643\u0644\u0649 \u0648\u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0627\u0644\u062f\u0642\u064a\u0642\u0629.<\/li>\n<\/ol>\n<p>\u062a\u0639\u062a\u0628\u0631 \u0647\u0630\u0647 \u0627\u0644\u0623\u0651\u0646\u0648\u0627\u0639 \u0645\u0647\u0645\u0651\u0629 \u062c\u062f\u0627\u064b \u0648\u0644\u063a\u0627\u064a\u0629 \u0647\u0630\u0647 \u0627\u0644\u0644\u062d\u0638\u0629 \u064a\u0639\u062f\u0651 \u0648\u062c\u0648\u062f\u0647\u0627 \u0648\u0627\u0643\u062a\u0634\u0627\u0641\u0647\u0627 \u0641\u064a \u0627\u0644\u062f\u062c\u0627\u062c \u0645\u0635\u062f\u0631 \u062e\u0644\u0627\u0641 \u0648\u062c\u062f\u0644 \u0628\u064a\u0646 \u0643\u062b\u064a\u0631 \u0645\u0646 \u0627\u0644\u0639\u0644\u0645\u0627\u0621.<\/p>\n<p>\u0627\u0644\u0649 \u0647\u0646\u0627 \u062a\u0642\u0631\u064a\u0628\u0627\u064b \u0623\u0643\u0645\u0644\u0646\u0627 \u0634\u0631\u062d\u0646\u0627 \u0627\u0644\u0645\u0628\u0633\u0651\u0637 \u062d\u0648\u0644 \u0628\u0646\u064a\u0629 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0648\u0641\u064a \u0645\u0627 \u064a\u0644\u064a \u0633\u0648\u0641 \u0646\u062a\u0637\u0631\u0651\u0642 \u0644\u0644\u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0642\u0648\u0645 \u0628\u0647\u0627 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0623\u0648 \u0642\u0646\u0627\u0629 \u0627\u0644\u062f\u0648\u0627\u062c\u0646 \u0627\u0644\u0647\u0636\u0645\u064a\u0629.<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u0627\u0644\u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 <\/strong><\/li>\n<\/ul>\n<p>\u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0638\u0647\u0627\u0631\u064a\u0629 \u0644\u0644\u0623\u0645\u0639\u0627\u0621\u060c \u062a\u0648\u062c\u062f \u0623\u064a\u0636\u0627\u064b \u062e\u0644\u0627\u064a\u0627 \u0645\u0646\u0627\u0639\u064a\u0629 \u0639\u0644\u0649 \u0637\u0648\u0644 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0645\u062b\u0644 GALT \u0648\u0647\u064a \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u062c\u0632\u0621 \u0645\u0646 \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u0644\u0645\u0641\u0627\u0648\u064a\u0629 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u063a\u0634\u0627\u0621 \u0627\u0644\u0645\u062e\u0627\u0637\u064a( (MALT) Mucous- Associated) \u0639\u0644\u0649 \u0639\u0643\u0633 \u0627\u0644\u062b\u062f\u064a\u064a\u0627\u062a \u0644\u0627 \u064a\u062d\u062a\u0648\u064a \u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u062f\u062c\u0627\u062c \u0627\u0644\u0644\u064a\u0645\u0641\u0627\u0648\u064a\u0629 (Lymphoid Tissues )\u0639\u0644\u0649 \u0639\u0642\u062f \u0644\u064a\u0645\u0641\u0627\u0648\u064a\u0629 \u0645\u063a\u0644\u0651\u0641\u0629\u00a0 \u0648\u064a\u0648\u062c\u062f \u0628\u062f\u0644\u0627\u064b \u0639\u0646 \u0630\u0644\u0643 \u0623\u0646\u0633\u062c\u0629 \u0644\u064a\u0645\u0641\u0627\u0648\u064a\u0629 \u0645\u0646\u062a\u0634\u0631\u0629 \u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u063a\u0634\u0627\u0621 \u0627\u0644\u0645\u062e\u0627\u0637\u064a.<\/p>\n<p>\u062a\u062a\u0639\u0631\u0651\u0636 \u062e\u0644\u0627\u064a\u0627GALT \u00a0\u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0644\u0645\u0633\u062a\u0636\u062f\u0651\u0627\u062a (Antigen) \u0623\u0643\u062b\u0631 \u0645\u0646 \u0623\u064a \u0646\u0633\u064a\u062c \u0622\u062e\u0631 \u0641\u064a \u0627\u0644\u062c\u0633\u0645 \u0648\u062a\u062a\u0648\u0627\u062c\u062f \u0641\u064a \u0645\u0646\u0627\u0637\u0642 \u0630\u0627\u062a \u0623\u0647\u0645\u064a\u0629 \u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0629 \u0639\u0644\u0649 \u0637\u0648\u0644 \u0627\u0644\u0623\u0645\u0639\u0627\u0621\u060c \u062a\u062a\u0636\u0645\u0651\u0646 \u062e\u0644\u0627\u064a\u0627 GALT \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0641\u064a \u0627\u0644\u062f\u0648\u0627\u062c\u0646 \u0639\u0644\u0649 \u0645\u0627 \u064a\u0644\u064a:<\/p>\n<ol>\n<li>\u0644\u0637\u062e\u0627\u062a \u0623\u0648 \u0628\u0642\u0639 \u0628\u0627\u064a\u0631 (PP).<\/li>\n<li>\u0644\u0648\u0632\u062a\u064a \u0627\u0644\u0623\u0639\u0648\u0631\u064a\u0646 (CT).<\/li>\n<li>\u0631\u062a\u062c \u0645\u064a\u0643\u0644 \u0623\u0648 \u0645\u0627\u064a\u0643\u0644.<\/li>\n<li>\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0644\u064a\u0645\u0641\u0627\u0648\u064a\u0629 \u062f\u0627\u062e\u0644 \u0627\u0644\u0628\u0637\u0627\u0646\u0629 \u0627\u0644\u0638\u0647\u0627\u0631\u064a\u0629 ((IELs) Intraepithelial Lymphocytes).<\/li>\n<li>\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0644\u064a\u0645\u0641\u0627\u0648\u064a\u0629 \u0641\u064a \u0627\u0644\u0635\u0641\u064a\u062d\u0629 \u0627\u0644\u0645\u062e\u0635\u0648\u0635\u0629 (LPL)\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u0642\u0639 \u062a\u062d\u062a \u0627\u0644\u0628\u0637\u0627\u0646\u0629 \u0627\u0644\u0638\u0647\u0627\u0631\u064a\u0629 \u0644\u0644\u0623\u0645\u0639\u0627\u0621 (Lamina propria Lymphocytes).<\/li>\n<\/ol>\n<p>\u062a\u062a\u0643\u0648\u0651\u0646 \u0627\u0644\u0628\u0646\u064a\u0629 \u0627\u0644\u062e\u0644\u0648\u064a\u0629 \u0644\u062e\u0644\u0627\u064a\u0627 GALT \u0627\u0644\u062f\u062c\u0627\u062c \u0628\u0634\u0643\u0644 \u0623\u0633\u0627\u0633\u064a \u0645\u0646 \u00a0IELs\u060c \u062e\u0644\u0627\u064a\u0627T\u060c \u0648\u062e\u0644\u0627\u064a\u0627\u03b1\u03b2 T \u060c \u0648\u062e\u0644\u0627\u064a\u0627 NK \u00a0\u060c \u0648\u062e\u0644\u0627\u064a\u0627 \u0628\u0644\u0639\u0645\u064a\u0629 \u0645\u062b\u0644 \u062e\u0644\u0627\u064a\u0627 (DC) \u0648\u062d\u064a\u062f\u0627\u062a \u0627\u0644\u0646\u0648\u0627\u0629 \u0648\u0627\u0644\u0628\u0644\u0627\u0639\u0645 (Monocytes &amp; Macrophages).<\/p>\n<p>\u0648\u0647\u0630\u0647 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0625\u0645\u0651\u0627 \u062a\u0642\u062a\u0644 \u0645\u0628\u0627\u0634\u0631\u0629 \u0645\u0633\u0628\u0651\u0628\u0627\u062a \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u063a\u0627\u0632\u064a\u0629 \u0623\u0648 \u062a\u0641\u0631\u0632 \u0627\u0644\u0633\u064a\u062a\u0648\u0643\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0624\u064a\u0651\u062f\u0629 \u0644\u0644\u0625\u0644\u062a\u0647\u0627\u0628\u0627\u062a \u0644\u0643\u064a \u062a\u062c\u0630\u0628 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u0623\u062e\u0631\u0649 \u0644\u062a\u0643\u0648\u064a\u0646 \u0627\u0644\u0625\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0644\u0644\u0645\u0636\u064a\u0641.<\/p>\n<p>\u062a\u0639\u0645\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 DC \u0648\u0627\u0644\u0628\u0644\u0639\u0645\u064a\u0627\u062a \u0623\u064a\u0636\u064b\u0627 \u0643\u062e\u0644\u0627\u064a\u0627 \u062a\u0642\u062f\u064a\u0645 \u0645\u0633\u062a\u0636\u062f\u0651 \u0641\u064a \u0627\u0644\u0623\u0639\u0636\u0627\u0621 \u0627\u0644\u0644\u0651\u0645\u0641\u0627\u0648\u064a\u0629 \u0627\u0644\u062b\u0627\u0646\u0648\u064a\u0629 \u0645\u062b\u0644 (PP)\u060c \u0643\u0645\u0627 \u062a\u0639\u0645\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0644\u0640 GALT \u0628\u0627\u0644\u062a\u0639\u0627\u0648\u0646 \u0644\u0628\u062f\u0621 \u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u062f\u0641\u0627\u0639 \u0627\u0644\u0645\u0636\u064a\u0641 \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u063a\u0632\u0648 \u0627\u0644\u0628\u0643\u062a\u064a\u0631\u064a.<\/p>\n<p>\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u0623\u0645\u0651\u064a\u0629 (Innate Immunity) \u0645\u0633\u0644\u0651\u062d\u0629 \u0628\u0623\u062c\u0647\u0632\u0629 \u0627\u0633\u062a\u0634\u0639\u0627\u0631 \u062e\u0627\u0635 \u0628\u0645\u0633\u0628\u0651\u0628\u0627\u062a \u0627\u0644\u0623\u0645\u0631\u0627\u0636\u060c \u0648\u0647\u0648 \u0645\u0627 \u064a\u0633\u0645\u0651\u0649 \u0628\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u062a\u0639\u0631\u0651\u0641 \u0639\u0644\u0649 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 (PRRs)\u060c \u062d\u064a\u062b \u062a\u062a\u0639\u0631\u0651\u0641 PRRs \u0639\u0644\u0649 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u0645\u0631\u0636\u0629 (PAMPs) \u0648\u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u0632\u064a\u0626\u064a \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u062a\u0644\u0641 (DAMPs)<\/p>\n<p>\u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0643\u0648\u0646 PRRs \u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u062e\u0644\u0627\u064a\u0627 (Toll- like receptors , scavenger receptors , C- \u00a0type lectins receptors ) \u00a0\u0623\u0648 \u0645\u0643\u0648\u0651\u0646\u0627\u062a \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0630\u0648\u0628\u0627\u0646 (pentraxins \u060c \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0631\u0628\u0637 LPS\u00a0 \u062a\u0648\u062c\u062f PRRs \u0639\u0644\u0649 \u0633\u0637\u062d \u0627\u0644\u062e\u0644\u064a\u0629 \u0641\u064a \u063a\u0634\u0627\u0621 \u0627\u0644\u0628\u0644\u0627\u0632\u0645\u0627 \u0648\u0641\u064a \u0627\u0644\u0633\u064a\u062a\u0648\u0628\u0644\u0627\u0632\u0645 \u0648\u062a\u062a\u0639\u0631\u0651\u0641 \u0639\u0644\u0649 \u0645\u0639\u0638\u0645 \u0645\u0633\u0628\u0628\u0651\u0627\u062a \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u0639\u0648\u064a\u0629. \u0631\u0628\u0651\u0645\u0627 \u062a\u0643\u0648\u0646 PRRs \u0627\u0644\u0623\u0643\u062b\u0631 \u0623\u0647\u0645\u064a\u0629\u060c \u0623\u0648 \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0644\u0651 \u0623\u0641\u0636\u0644 \u0648\u0635\u0641 \u0644\u0647\u0627 \u0647\u064a \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a (TLR) \u062a\u062a\u0639\u0631\u0651\u0641 \u0647\u0630\u0647 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u062d\u0633\u0651\u064a\u0629 \u0639\u0644\u0649 \u0645\u0633\u0628\u0651\u0628\u0627\u062a \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u0631\u0648\u0627\u0628\u0637 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0639\u0644\u0649 \u0627\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0627 \u0623\u0648 \u0645\u0633\u0628\u0651\u0628\u0627\u062a \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0623\u062e\u0631\u0649)\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u0634\u0645\u0644\u060c \u0639\u0644\u0649 \u0633\u0628\u064a\u0644 \u0627\u0644\u0645\u062b\u0627\u0644Flagellin (TLR5) \u060c LPS (TLR4) \u0648 CpG-DNA (TLR21) \u0648\u0625\u0644\u0649 \u0647\u0630\u0647 \u0627\u0644\u0644\u062d\u0638\u0629 \u0647\u0646\u0627\u0644\u0643 \u0623\u0628\u062d\u0627\u062b \u0648\u0623\u0628\u062d\u0627\u062b \u0644\u0645\u0639\u0631\u0641\u0629 \u0623\u062f\u0642\u0651 \u0627\u0644\u062a\u0641\u0627\u0635\u064a\u0644 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0639\u0645\u0644 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u0623\u0645\u0639\u0627\u0621\u060c \u0648\u0643\u064a\u0641\u064a\u0629 \u0645\u062d\u0627\u0631\u0628\u062a\u0647\u0627 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0627\u0648 \u0627\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0627 \u0627\u0648 \u0627\u0644\u0637\u0641\u064a\u0644\u064a\u0627\u062a \u0627\u0648 \u0627\u064a\u0651 \u0645\u0648\u0627\u062f\u0651 \u062a\u062d\u0627\u0648\u0644 \u0623\u0646 \u062a\u062e\u062a\u0631\u0642 \u0628\u0637\u0627\u0646\u0629 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0648\u0627\u0644\u062f\u062e\u0648\u0644 \u0627\u0644\u0649 \u0628\u0627\u0642\u064a \u0623\u0639\u0636\u0627\u0621 \u0627\u0644\u062f\u062c\u0627\u062c\u0629.<\/p>\n<p>\u064a\u0639\u062f\u0651 \u0627\u0644\u0625\u0647\u062a\u0645\u0627\u0645 \u0628\u0633\u0644\u0627\u0645\u0629 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0639\u0648\u064a\u0629 \u0623\u0645\u0631\u0627\u064b \u0636\u0631\u0648\u0631\u064a\u0627\u064b\u060c \u0644\u0630\u0644\u0643 \u064a\u062c\u0628 \u0639\u062f\u0645 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u062a\u064a \u062a\u0624\u062f\u0651\u064a \u0627\u0644\u0649 \u062a\u0644\u0641 \u0628\u0637\u0627\u0646\u0629 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0648\u0627\u0644\u062a\u064a \u0644\u0627 \u064a\u0635\u0631\u0651\u062d \u0628\u0647\u0627 \u0645\u0646 \u0642\u0628\u0644 \u0627\u0644\u0634\u0631\u0643\u0627\u062a \u0627\u0644\u0645\u0635\u0646\u0651\u0639\u0629 \u0648\u062d\u0633\u0628 \u0631\u0623\u064a \u0627\u0644\u0639\u0644\u0645\u0627\u0621 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u0645\u0648\u0627\u062f\u060c \u0643\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0639\u0642\u0651\u0645\u0627\u062a \u0623\u0648 \u0627\u0644\u064a\u0648\u062f 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\u0627\u0631\u062a\u0628\u0627\u0637\u0627\u064b \u0645\u0628\u0627\u0634\u0631\u0627\u064b \u0628\u0627\u0644\u0648\u0635\u0648\u0644 \u0644\u0644\u0623\u0648\u0632\u0627\u0646 \u0627\u0644\u0642\u064a\u0627\u0633\u064a\u0629 \u0641\u064a \u0632\u0645\u0646 \u0642\u064a\u0627\u0633\u064a \u0648\u062c\u064a\u0632 \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u062a\u062d\u0642\u064a\u0642 \u0623\u0641\u0636\u0644 \u0631\u0628\u062d\u064a\u0629 \u0645\u0646 \u062a\u0631\u0628\u064a\u0629 \u0642\u0637\u0639\u0627\u0646 \u0627\u0644\u062f\u0648\u0627\u062c\u0646.<\/li>\n<\/ol>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u0627\u0644\u0645\u0635\u0627\u062f\u0631:<\/strong><\/p>\n<ol>\n<li>Aminul Islam. 2022. Gut Health, the pillar of entire health and production success, Engormix.com.<\/li>\n<li>Theo Niewold. 2015. Intestinal health, Key to maximize growth performance in livestock. Wageningen. Academic publisher. Netherlands.<\/li>\n<li>Sturkie&#8217;s Avian Physiology 6th Edition. Kindle Edition. 2014.<\/li>\n<li>Field Experiences of authors.<\/li>\n<\/ol>\n<p>\u0625\u0639\u062f\u0627\u062f:<\/p>\n<p><strong>\u062f. \u0645\u062d\u0645\u062f \u0627\u0644\u0632\u0648\u0642\u0631\u064a<\/strong><\/p>\n<p>\u0627\u0633\u062a\u0634\u0627\u0631\u064a \u062a\u063a\u0630\u064a\u0629 \u0627\u0644\u062f\u0648\u0627\u062c\u0646 \u0648\u062a\u0635\u0646\u064a\u0639 \u0627\u0644\u0623\u0639\u0644\u0627\u0641<\/p>\n<p>\u0627\u0644\u064a\u0645\u0646<\/p>\n<p>\u0648<\/p>\n<p><strong>\u062f. \u0645\u064a\u0644\u0627\u062f \u0625\u0628\u0631\u0627\u0647\u064a\u0645 \u0639\u0631\u064a\u0628\u064a<\/strong><\/p>\n<p>\u0627\u0633\u062a\u0634\u0627\u0631\u064a \u0623\u0645\u0631\u0627\u0636 \u0648\u0645\u0646\u0627\u0639\u0629 \u0627\u0644\u062f\u0648\u0627\u062c\u0646<\/p>\n<p>\u0627\u0644\u0639\u0631\u0627\u0642<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u062a\u0639\u062a\u0628\u0631 \u0642\u0646\u0627\u0629 \u0627\u0644\u062f\u0648\u0627\u062c\u0646 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